Laboratory of Bioinformatics Analyses for Genomics and Metabolism
Prokaryotes —bacteria and archaea— are diverse, ubiquitous organisms with vast impacts on health, soil, and ocean ecosystems. Large-scale genome sequencing and pangenomics have revealed their molecular diversity, especially the role of Mobile Genetic Elements (MGEs). Pangenomics analyzes genetic variability across
Prokaryotes (i.e. bacteria and archaea) constitute a fascinating field of living organisms, representing remarkable diversity and ubiquity. Their impact on the biosphere is immense, influencing human and animal health, soil and ocean biogeochemistry, and much more. Large-scale exploration of microbial
Funded by the French Priority Plan on antibioresistance, the ABRomics project aims at developing an online community-driven platform to scale up and improve surveillance and research on antibiotic resistance from a One Health perspective. The platform is made of: The
The aim of this PhD thesis is to achieve new methodological developments for the comparative study of pangenomes. This will involve the development of new bioinformatic methods for inter-pangenome comparisons, which will be particularly based on the developments carried out
PPanGGOLiN (Gautreau et al. 2020) is a software suite used to create and manipulate prokaryotic pangenomes from a set of either genomic DNA sequences or provided genome annotations. It is designed to scale up to tens of thousands of genomes.
Many comparative genomic studies try to get a grasp on the overall gene content of a species. However, with the current explosion of available genomic data, it becomes more complex to use all-vs-all genome comparison approaches. Over the last years,
Horizontal gene transfer (HGT) is a major source of variability in prokaryotic genomes. Regions of Genome Plasticity (RGPs) are clusters of genes located in highly variable genomic regions. Most of them arise from HGT and correspond to Genomic Islands (GIs).
Prokaryotes —bacteria and archaea— are diverse, ubiquitous organisms with vast impacts on health, soil, and ocean ecosystems. Large-scale genome sequencing and pangenomics have revealed their molecular diversity, especially the role of Mobile Genetic Elements (MGEs). Pangenomics analyzes genetic variability across
Localisé au CEA/Genoscope, un centre de recherche scientifique dédié à la génomique environnementale, le Laboratoire d’Analyses Bioinformatiques pour la Génomique et le Métabolisme (LABGeM, UMR8030, labgem.genoscope.cns.fr) s’intéresse à l’analyse et à l’exploration de la diversité des microorganismes et de leur