Laboratory of Bioinformatics Analyses for Genomics and Metabolism
Many comparative genomic studies try to get a grasp on the overall gene content of a species. However, with the current explosion of available genomic data, it becomes more complex to use all-vs-all genome comparison approaches. Over the last years,
Horizontal gene transfer (HGT) is a major source of variability in prokaryotic genomes. Regions of Genome Plasticity (RGPs) are clusters of genes located in highly variable genomic regions. Most of them arise from HGT and correspond to Genomic Islands (GIs).
MICheck (Microbial Genome checker), is a web software enabling rapid verification of sets of annotated genes and frameshifts (syntaxic annotation), in complete bacterial genomes available in public databanks. website: https://mage.genoscope.cns.fr/tools/micheck Documentation and publication: Cruveiller et al. (2005) Nucleic Acids Res. Jul 1;33(Web
AMIGene (Annotation of MIcrobial Genes) is an application for automatically identifying the most likely CoDing Sequences (CDSs) in a large contig or a complete bacterial genome sequence. website: www.genoscope.cns.fr/agc/tools/amigene Documentation and publication : Bocs et al. (2003) Nucleic Acids Res. 13(31) 3723-3726.
In order to extend the range of tools available to MicroScope users, we aim to develop the platform functionalities dedicated prediction, annotation and exploration of genomic regions. These genomic regions include specialized gene clusters (ie, encoding for secretion systems, CRISPR
Cyanobacteria are an ancient lineage of photosynthetic bacteria, which are prolific producers of secondary metabolites. Hundreds of bioactive compounds with diverse chemical structures , such as toxins and molecules of pharmaceutical interest, have been characterized from cyanobacteria.
Contexte : Le Genoscope (CEA, Institut de Biologie François Jacob) est un centre de référence français en génomique environnementale qui réalise des analyses à grande échelle pour la compréhension des écosystèmes, notamment dans le contexte des grands changements environnementaux. Son
Analyse pangénomique des voies métaboliques chez les archées Description Lieu : Vous serez accueilli au sein du Laboratoire d’Analyses Bioinformatiques pour la Génomique et le Métabolisme (LABGeM, UMR8030, https://labgem.genoscope.cns.fr) du Genoscope (Institut de biologie François Jacob – CEA – Evry),