Laboratory of Bioinformatics Analyses for Genomics and Metabolism
Le projet DREAM (PPR Antibiorésistance) vise à étudier l’impact des antibiotiques sur la modulation de la sélection de la résistance aux antibiotiques dans le microbiote intestinal humain [1]. Les réponses aux antibiotiques varient fortement d’un individu à l’autre, etdécrypter les
The climate emergency requires us to move from an economy based on fossil fuels to a sustainableenergy mix, allowing a transition from our carbon-based societies to a more sustainable economy.In this context, the valorisation of lignocellulosic biomass (LCB) is central
Launched in December 2022, the Horizon Europe BlueRemediomics project aims to harness the untapped potential of marine microbial resources. Lasting four years, and bringing together an international consortium of experts including the Metabolic Genomics UMR (Genoscope/CEA-Jacob), this project will develop
The Phaeoexplorer project (https://phaeoexplorer.sb-roscoff.fr/home/) aims to generate transcriptome data and annotated genome assemblies for a broad range of brown algal species at different phylogenetic distances from the model brown alga Ectocarpus. It is made in collaboration with the algal genetics
Background Today, thanks to the development of metagenomics, our knowledge of microbial diversity has greatly changed. Whereas previously cellular organisms were seen more as independent entities, today we know that they organize themselves into complex microbial communities made up of
The ALADIN project aims to build an integrated and distributed technological platform which will rely on the combination of combinatory genetics with artificial intelligence. It will enable the exploration of natural molecular diversity, its appropriation to build new purpose-based catalysts
The current trend in Chemistry is to perform the energy transition successfully by considering cheaper and greener alternatives. This can be achieved by the substitution of some chemical steps by biocatalyzed ones or the design of new enzymatic routes, thus
We developed a method to classify proteins of a family based on their conserved genomic contexts. Each protein genomic context is compared against all others to determine syntenies. A graph is generated where nodes are input proteins connected by edges
Prokaryotes —bacteria and archaea— are diverse, ubiquitous organisms with vast impacts on health, soil, and ocean ecosystems. Large-scale genome sequencing and pangenomics have revealed their molecular diversity, especially the role of Mobile Genetic Elements (MGEs). Pangenomics analyzes genetic variability across
Localisé au CEA/Genoscope, un centre de recherche scientifique dédié à la génomique environnementale, le Laboratoire d’Analyses Bioinformatiques pour la Génomique et le Métabolisme (LABGeM, UMR8030, labgem.genoscope.cns.fr) s’intéresse à l’analyse et à l’exploration de la diversité des microorganismes et de leur