The genomic data derived from the actual sequencing technologies are of limited interest as such, and in addition, this flood of data tends to increase the number of genes whose functions remain totally unknown. The main objective of our research team is to extract biological knowledge from prokaryotic organisms through the development of bioinformatics tools integrating very diverse sources: raw sequencing data, results of in silico analysis tools, data derived from generic or specific databases, omics data such as transcriptomic, proteomic, metabolomic, and phenomic data. These tools and data are generally made available through MicroScope, an integrated platform dedicated to microbial genome annotation and comparative analysis MicroScope, which offers a free-of-charge service to the scientific community for the integration of new (meta)-genomes.
Scientific activities of the LABGeM are centered on the bioinformatics (and biostatistics) analysis of
Microbial (meta)genomes: dynamics and evolution of bacterial genomes, functional annotation of (meta)genomes, taxonomic assignation of metagenomic data
Bacterial metabolism & System Biology: prediction, curation and comparison of metabolic networks, investigation for ‘orphan’ enzymes, discovery of new enzymatic activities. These R&D activities participate to one of the main research topic of the UMR “Genomics Metabolics”: the elucidation of the metabolism of prokaryotes through the discovery of new chemical reactions catalyzed by the living world.
Through diverse research projects, in-house or conducted in national or international collaborations, we focus on biological applications in the following domains: Epidemiology and health, Environmental Biology and Biotechnology (green and white).