The secondary metabolite gene cluster prediction tool antiSMASH has been updated to version 6.1.1 (Blin et al, 2021) on the MicroScope platform. This version increases the number of supported cluster types from 58 to 71, with a focus on the rules for ribosomally synthesized and post-translationally modified peptides (RiPPs). Outside of RiPPs, antiSMASH added support for BGCs producing thioamide-containing non-ribosomal peptides, tropodithietic acid, Serratia-type prodigiosins, non-alpha poly-amino acids and pyrrolidines.
These prediction results can be queried in the Search by keyword functionality. They are also cross referenced in the pangenome-RGP page. Indeed for each region of genomic plasticity (RGP), we indicate if this region contains predicted biosynthetic gene clusters.
K. Blin et al., antiSMASH 6.0: improving cluster detection and comparison capabilities, Nucleic Acids Research, Volume 49, Issue W1, 2 July 2021, Pages W29–W35, https://doi.org/10.1093/nar/gkab335