Research Highlights: Pseudomonas putida KT2440, a standard organism for use as a versatile chassis for both fundamental and biotechnological endeavors.

labgem MicroScope Announce

The re-sequencing of the soil bacterium Pseudomonas putida KT2440 genome sequence, coupled to a complete upgrade of its sequence annotations allowed us to revisit the astonishing capacities that are encoded in the genetic complement of this unique microorganism. The overall examination not only accounts for some of the known stress tolerance traits known in P. putida but also recognizes the capacity of this bacterium to perform difficult redox reactions, thereby multiplying its value as a platform microorganism for industrial biotechnology.

Schematic representation of the catabolism of aromatic compounds to central metabolites in P. putida KT2440. (Source Belda et al., 2016)

References:

Belda E, van Heck RG, Lopez-Sanchez MJ, Cruveiller S, Barbe V, Fraser C, Klenk HP, Petersen J, Morgat A, Nikel PI, Vallenet D, Rouy Z, Sekowska A, Martins Dos Santos VA, de Lorenzo V, Danchin A, Médigue C. The revisited genome of Pseudomonas putida KT2440 enlightens its value as a robust metabolic chassis. Environ Microbiol. 2016 Feb 23.

Pablo I Nikel, Max Chavarría, Antoine Danchin,  Víctor de Lorenzo. From dirt to industrial applications: Pseudomonas putida as a Synthetic Biology chassis for hosting harsh biochemical reactions Current Opinion in Chemical Biology, Volume 34, October 2016, Pages 20–29

 

Research Highlights: Pseudomonas putida KT2440, a standard organism for use as a versatile chassis for both fundamental and biotechnological endeavors.